I find most content to read via the big stream.
1 Social reader / big stream
The big stream is basically a bunch of people that I follow.
I don't use Twitter for my reader. I use a social reader for this. I follow people on their personal websites, or on Twitter, and read all these posts in the reader.
I wrote a bit more about how I organise feeds in my reader here.
2 Replying / storing
Usually what I see in the big stream are either ideas from someone that I might want to write a reply to, or a link to an article I might want to read later. I save articles in to Wallabag. A short reply I'll write there and then, a longer one I will probably save the post into my note-taking app.